目的：探讨万古霉素鞘内注射联合腰大池持续引流治疗颅脑术后颅内感染的临床效果。方法选择我院收治的80例颅脑术后颅内感染患者为研究对象，随机分为对照组和观察组，对照组采用万古霉素鞘内注射治疗，观察组在对照组的基础上加用腰大池持续引流治疗。比较2组的治疗效果，治疗前后脑脊液常规检查改善情况及治疗过程中不良反应发生情况。结果观察组总有效率为92％，显著高于对照组的73.3％，差异有统计学意义（ P＜0.05）。治疗后脑脊液白细胞计数、蛋白质显著低于治疗前，葡萄糖显著高于治疗前，观察组改善效果更显著。结论万古霉素鞘内注射联合腰大池持续引流治疗颅脑术后颅内感染，可显著改善感染症状，对患者损伤小，为理想的治疗方法，值得临床推广应用。%Objective To study the clinical effect of vancomycin intrathecal injection and continuous drainage from lumbar cistern in treatment of intracranial infection after craniocerebral. Methods 80 patients with intracranial infection after cranioce‐rebral operation in our hospital were randomly divided into the control group (receiving vancomycin intrathecal injection ) and observation group (receiving intrathecaland vancomycin and continuous external lumbar drainage ).The treatment effect ,routine examination of CSF before and after treatment and adverse reactions occurred in the treating process were observed.Results The total effective rate of observation group (92% ) was significantly higher than that of control group (73.3% ) ,which was statistically different (P< 0.05). The leukocyte count and protein in cerebrospinal fluid after treatment was obviously lower than these before the treatment ,while glucose was significantly higher than that before the treatment ,and the improvement was more prominent in the observation group.Conclusion Combination of intrathecal vancomycin and continuous external lum‐bar drainage in treatment of intracranial infection after craniotomy can significantly improve symptoms ,with slight injury , which is worthy of application.
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