正常人汉字工作记忆功能磁共振脑激活区改变的研究

摘要

目的 探讨正常人汉字任务下脑激活区的改变.方法 对40例正常人进行汉字工作记忆功能磁共振扫描.结果 汉字工作记忆任务下,编码、保持及提取期均有额叶、楔前叶、楔叶、边缘叶及扣带回的正向激活,且有侧脑室及脑脊液在编码及保持期的正向激活和在提取期的负向激活.除共同激活脑区外,编码期所有激活脑区均为正向激活,保持期正向激活脑区有中央前回、杏仁核、上后扣带皮层(BA 31),负向激活脑区有颞中回、顶叶、角回,提取期正向激活脑区有尾状核.结论 汉字任务下,脑激活区的改变除皮层及皮层下结构,还有侧脑室及脑脊液的激活.%Objective To study the change in the brain activation area underwent Chinese characters working memory by u-sing functional magnetic resonance (fMRI)in healthy persons.Methods Forty healthy persons underwent fMRI while performing Chinese characters working memory task by using block design.Results Frontal lobe,precuneus,cuneus,limbic Lobe,cingulate gyrus were activated in the period of encode,maintain and extraction under Chinese characters working memory,cerebro-spinal and fluid lateral ventricle were activated during the encode and maintain period and were negatively activated in extraction period.In ad-dition to the common activated brain area,all activated brain regions were positively activated during encode period.During the maintain period,precentral gyrus,amygdale and cingulate cortex after 31 (BA)were positively activated and frontal and temporal brain regions and angular gyrus were negatively activated.During the extraction periods,the activated brain regions were caudate nucleus and Broca area.Conclusion In addition to cortical and cortical and subcortical structures,cerebro-spinal and fluid lateral ventricle are also activated under the Chinese characters working memory.