SDF-1、CXCR4、MVD联合检测在多发性骨髓瘤患者预后评估中的应用

摘要

目的 探讨基质细胞衍生因子-1(SDF-1)、受体趋化因子(CXCR4)、微血管密度(MVD)联合检测在多发性骨髓瘤患者预后评估中的应用.方法 选取2015年4月至2018年6月在晋城大医院进行多发性骨髓瘤治疗的76例患者作为研究组,另选取同期30例骨髓象正常者作为对照组.比较两组SDF-1、CXCR4、MVD表达水平及相关关系,并分析年龄、性别、国际分期系统(ISS)分期、免疫球蛋白分型及SDF-1、CXCR4、MVD与患者预后之间的关联.结果 研究组SDF-1及CXCR4阳性程度均高于对照组(P均<0.05),且研究组MVD水平也高于对照组(P<0.05);研究组SDF-1及CXCR4表达与MVD水平呈正相关关系(P<0.05).分析患者预后影响因素表明,患者年龄、ISS分期、免疫球蛋白分型及SDF-1及CXCR4表达水平、MVD计数能够作为判断该疾病预后的因素.结论 SDF-1、CXCR4、MVD对多发性骨髓瘤病情的发展可能起一定的促进作用,且均为影响患者预后的因素,故通过检测患者体内SDF-1、CXCR4、MVD水平,可对其预后进行有效评估.%Objective To investigate the application of combined detection of stromal cell derived factor-1 ( SDF-1 ) , chemokine receptor 4 ( CXCR4 ) and microvessel density ( MVD ) in evaluating the prognosis of patients with multiple myeloma. Methods Seventy-six patients with multiple myeloma in Jincheng General Hospital from April 2015 to June 2018 were selected as study group, and 30 patients with normal bone marrow in the same period were selected as control group. The expression levels of SDF-1, CXCR4 and MVD and their correlations were compared between the two groups. The correlation of age, sex, international staging system ( ISS ) stage, immunoglobulin typing, SDF-1, CXCR4, MVD with prognosis was analyzed. Results The positive levels of SDF-1 and CXCR4 in study group were significantly higher than those in control group ( P<0. 05 ) , and the MVD level in study group was also significantly higher than that in control group ( P<0. 05 ) . The expression of SDF-1 and CXCR4 was positively correlated with MVD level in study group ( P<0. 05 ) . Analysis of prognostic factors showed that age, ISS stage, immunoglobulin typing, expression of SDF-1 and CXCR4, MVD count could be used as prognostic factors for multiple myeloma. Conclusions SDF-1, CXCR4 and MVD may play positive roles in promoting the development of multiple myeloma, and they are all factors affecting the prognosis. Therefore, the prognosis of patients can be effectively evaluated by detecting the levels of SDF-1, CXCR4 and MVD.