Galectin-1、Galectin-3、Galectin-9在宫颈鳞状细胞癌中的表达及其临床意义

摘要

Objective To investigate the expression and clinical significance of Galectin-1 ,Ga-lectin-3 and Galectin-9 protein in cervical squamous cell carcinoma. Methods Selected 78 cases of cer-vical squamous cell carcinoma specimens of paraffin,using immunohistochemical method to detect the ex-pression of 78 cases of Galectin-1 ,Galectin-3 and Galectin-9 in plasma cervical squamous cell carcinoma specimens of paraffin blocks,and analyzed the correlation between the expression and the clinical features of cervical squamous cell carcinoma. Results The positive expression rates of Galectin-1 and Galectin-3 in cervical squamous cell carcinoma tissue was 89. 7% and 84. 6% respectively,and they were significantly higher than those in normal cervical tissue( 12. 8% and 15. 4%),the differences were statistically significant( P﹤0. 05 );the positive expression rate of Galectin-9 in cervical squamous cell carcinoma tissue was 17. 9%,and that in normal cervical tissues was 14. 1%,there was no statisti-cal significance( P﹥0. 05 ). The expression of Galectin-1 and Galectin-3 in cervical squamous cell car-cinoma were all related with histological grade,FIGO clinical stage,myometrial infiltration,lymph node metastasis,extrauterine spread,and the differences were statistically significant(all P﹤0. 05);The ex-pression of Galectin-9 in cervical squamous cell carcinoma had no specific correlation with histological grade,FIGO clinical stage,myometrial infiltration,lymph node metastasis,extrauterine spread,the differences were not statistically significant( P﹥0. 05 ). Conclusions The high expression of Galectin-1 and Galectin-3 and low expression of Galectin-9 have important role in the occurrence and development of squamous cell carcinoma of the cervix,and they have a certain significance in judging the biological be-havior of cervical squamous cell carcinoma.%目的：探讨宫颈鳞状细胞癌组织中 Galectin-1、Galectin-3、Galectin-9蛋白的表达及其临床意义。方法选取宫颈鳞状细胞癌标本蜡块78例，采用免疫组织化学方法对宫颈鳞状细胞癌标本蜡块78例组织中的Galectin-1、Galectin-3和 Galectin-9蛋白表达进行检测，分析其表达与宫颈鳞状细胞癌临床病理特征的关系。结果 Galectin-1、Galectin-3在宫颈鳞状细胞癌组织中阳性表达率分别为89.7%、84.6%，均明显高于其正常宫颈组织中阳性表达率（12.8%、15.4%），差异均有统计学意义（P﹤0.05）；Galectin-9在宫颈鳞状细胞癌组织阳性表达率为17.9%，与正常宫颈组织Galectin-9阳性表达率（14.1%）比较差异未见统计学意义（P﹥0.05）。可以认为Ga-lectin-1、Galectin-3在宫颈鳞状细胞癌表达与组织学分级、临床FIGO分期、肌层浸润程度、淋巴结转移、宫外扩散有关，差异有统计学意义（P﹤0.05）；尚不能认为Galectin-9在宫颈鳞状细胞癌表达与组织学分级、临床FIGO分期、肌层浸润程度、淋巴结转移、宫外扩散相关，差异未见统计学意义（ P﹥0.05）。结论 Galectin-1、Galectin-3的高表达和Galectin-9的低表达在宫颈鳞状细胞癌的发生、发展中具有重要作用，对判断宫颈鳞状细胞癌患者的生物学行为具有一定的意义。