体外受精-胚胎移植120个妊娠周期中移植胚胎形态学分析

摘要

Objective To provide reliable parameter to select transferring embryos in in vitro fertilization-embryo transfer. Methods 453 embryos from 120 pregnant cycles were retrospectively analyzed. Results Among 120pregnancies, 75 were singleton pregnancies and 45 multiple pregnancies. The ratio of 4-cell stage embryos in singleton pregnancies was 47.3%, and increased to 53.2% in twin pregnancies and 72.5% in triplet pregnancies. The more the≥4-cell stage embryos transfered, the more the embryos implanted( P ＜ 0.05). Conclusion Morphology can be considered as a parameter to select transferring embryos, but how to determine an optimal number of embryos and decrease multiple pregnancy rate at the meantime still needs prospective study.%目的为体外受精和胚胎移植临床中选择移植胚胎提供参考指标。方法回顾性分析在本中心行IVF-ET治疗并在取卵后第2天移植胚胎的120个妊娠周期共453个移植胚胎的资料。结果 120个治疗周期中单胎75例，双胎33例，3胎10例，4胎以及5胎各1例。4细胞期胚胎所占的比例从单胎的47.3％增至双胎的53.2％和3胎的72.5％，妊娠胎数随移植胚胎中≥4细胞期胚胎的增多而明显增加(X2=10.813，P＜0.05)。结论形态学可以作为选择移植胚胎的参考指标之一，但如何在保证妊娠率的同时减少移植胚胎的数目而降低多胎妊娠率还需进一步的前瞻性研究。