Objective Investigate the cause of intrauterine infection in late pregnancy, the main pathogens, its impact on maternal and child outcomes and prevention measures. Methods International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine,253 cases was diagnosed of intrauterine infection in late pregnancy between January 1, 2006 and December 31 ,2011 were analyzed retrospectively. Results The hospital in the past of six years the number of cases to intrauterine infection accounted for 0. 41 % of the same period the total number of deliveries, including preterm intrauterine infection accounted for 2. 36% of the total number of premature delivery. Intrauterine infection is associated with premature rupture of membranes, to the time of treatment, the production process duration and the number of vaginal examinations and others. The main pathogens of intrauterine infection followed by GBS (20. 6% ) , escherichia coli (19. 4% ) , enterococcus faecalis (18. 9% ). Of the intrauterine infection patients, rate of eesarean section 76.1% , puerperal infection 14. 2% , neonatal infection 20. 9% , perinatal mortality 3. 2%. Conclusions To strengthen the health care during pregnancy and the management of treatment, the production process. Active prevention and timely diagnosis and treatment of intrauterine infection can improve the prognosis of female and children.%目的 探讨晚期妊娠宫内感染的病因、主要致病菌、对母儿的影响及防治措施.方法 对上海交通大学医学院附属国际和平妇幼保健院2006年1月1日至2011年12月31日诊断为晚期妊娠宫内感染的253例患者资料进行回顾性分析.根据分娩孕周分成早产组(82例)及足月组(171例),比较两组病例的临床结果及母儿预后等.结果 6年来宫内感染的病例数占同期分娩总数的0.41％,其中早产宫内感染占早产总数的2.36％.早产组胎膜早破率、产褥感染率、新生儿感染率及围产儿病死率均高于足月组(P＜0.05).宫内感染主要致病菌群依次为B族链球菌(20.6％)、大肠埃希菌(19.4％)、粪肠球菌(18.9％).宫内感染病例剖宫产率76.7％、产褥感染率14.2％、新生儿感染率20.9％、围产儿病死率3.2％.结论 宫内感染尤其是早产宫内感染对母儿预后造成严重威胁.应加强孕期保健及期待治疗、产程过程中的管理,积极预防与及时诊治宫内感染以改善母儿预后.
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