乳腺癌术后再发卵巢癌的预防与诊治

摘要

Breast cancer remains the most common cancer in the female.If patients had unmanried history,family history,the history of three-negative breast cancer or oral selective estrogen antagonists and BRCA1/BRCA2 mutations,we should be specially alerted that the patients after operation for breast cancer might have the possibility of happening ovarian cancerThere are several methods including gene detection,clinical screening and risk-redueing salpingooophorectomy (RRSO),which can prevent incidence of ovarian cancer after operation for breast cancer.The patients should receive treatment as soon as possible.The proportion of patients with ≥5 years of interval incidence time is the highest,which means the longterm follow-up is necessary.%乳腺癌是女性最常见的恶性肿瘤,如有未婚未育史、家族遗传史、三阴性乳腺癌、术后口服选择性雌激素拮抗剂及BRCA1/BRCA2基因突变者,应特别警惕乳腺癌术后再发卵巢癌的可能.通过基因检测、临床筛查及降风险输卵管卵巢切除术(risk-reducing salpingo-oophorectomy,RRSO)的方法,可以有效预防乳腺癌术后再发卵巢癌.而对于乳腺癌术后已经发现卵巢癌者,应尽早接受治疗.乳腺癌与卵巢癌的发病间隔≥5年的患者所占比例最高,提示获得长期生存的乳腺癌患者也要警惕卵巢癌的发生.