Controlled release composition, drug, drug for the prevention or cure of disease, or a contraceptive agent, agent for preventing breast cancer recurrence after premenopausal breast cancer, and methods of prevention or cure disease, or a method of contraception, of producing the controlled release composition, and for the prevention of breast cancer recurrence after the premenopausal breast cancer operation

摘要

"COMPOSITION OF CONTROLLED RELEASE, MEDICINAL PRODUCT, DRUG FOR PREVENTION OR CURE FOR DISEASES, OR A CONTRACEPTIVE AGENT, AGENT FOR PREVENTION OF BREAST CANCER RECURRENCE AFTER THE OPERATION OF PREMENOPAUSAL AND PREEMPOSE, AND PREMENOUS BREAST CANCER CURE OF DISEASES, OR A METHOD OF CONTRACEPTION, PRODUCTION OF CONTROLLED RELEASE COMPOSITION, AND FOR PREVENTION OF BREAST CANCER RECURRENCE AFTER PREMENOPAUS BREAST CANCER OPERATION ". A controlled release composition is provided containing a physiologically active substance at high content, which suppresses initial over-release, and achieves a stable release rate over a long period of time. A controlled release composition comprising: (1) a physiologically active substance or salt thereof in an amount from about 14% (w / w) to about 24% (w / w) based on the weight of the total composition, (2 ) hydroxy-naphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or its salt, and (3) a lactic acid polymer or salt thereof having a weight average molecular weight of 15,000 to 50,000 wherein the content of polymers having molecular weights of 5,000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxy naphthoic acid or salt thereof to said physiologically active substance or salt thereof it's from 3: 4 to 4: 3.