Objective To observe the therapeutic effect of propranolol with 1 064 nm Nd:YAG laser on proliferating hemangioma in body surface.Methods 97 patients with proliferating hemangiomas in body surface were randomly assigned to three groups:A group(32 patients were treated by propranolol with 1 064 nm Nd:YAG laser),B group(35 patients were treated by 1 064 nm Nd:YAG laser),C group (30 patients were treated by propranolol).Their visual analog scores,clinical outcomes and adverse events were compared respectively.Results 18 weeks later,A group had a mean visual analog score of 65.50 ±16.55,compared with 54.03 ± 20.13 in B group,28.08 ± 30.34 in C group( P ＜ 0.05 ) ;24 weeks later,the mean visual analog scores of three groups were 76.88 ± 19.05、63.89 ± 19.43 and 45.48 ± 31.86(P ＜0.05).After 24 weeks' treatment,9 cases ( 28.1％ ) in A group,3 cases ( 8.6％ ) in B group,1 cases ( 4.0％ ) in C group obtained complete healing( P ＜ 0.05 ).To effect of adverse events in body surface,the mean score of B group was higher than the scores of A group and C group ( P ＜ 0.05 ).Conclusions Propranolol with 1 064 nm Nd:YAG laser is effective and safe in the treatment of proliferating hemangioma.%目的 评价普萘洛尔联合1 064 nm Nd:YAG激光治疗体表增殖期血管瘤的疗效.方法 97例体表增殖期血管瘤患儿,随机分为普萘洛尔与激光联合治疗组(A组,32例)、激光治疗组(B组,35例)和普萘洛尔治疗组(C组,30例)3组,分别比较3组患者治疗后的直观类比标度评分、整体疗效,以及不良反应等.结果 治疗后第18周,A、B、C3组的直观类比标度评分平均分分别为65.50±16.55、54.03±20.13、28.08±30.34 (P ＜0.05)；第24周分别为76.88±19.05、63.89±19.43、45.48±31.86(P ＜0.05).治疗24周后,A、B、C3组中,分别有9例(28.1％)、3例(8.6％)、1例(4.0％)痊愈(P＜0.05)；皮肤不良反应的影响程度评分,B组高于A和C组(P＜0.05).结论 普萘洛尔联合1 064 nm Nd:YAG激光是治疗体表增殖期血管瘤的一种安全有效的方法.
展开▼
