黄蜀葵花总黄酮联合格列吡嗪对糖尿病肾病模型大鼠的治疗作用

摘要

Objective To investigate the effects of total flavone of Abelmoschl manihot (TFA) combined with glipizide on GK model rats of diabetic nephropathy.Methods The GK model rats were induced by high-calorie and high-protein diet.The level of glycosylated hemoglobin,blood fat,indothelin,urinary microalbumin,blood rheology,renal function,indexes and pathology of renal were determined to evaluate the auxiliary therapeutic effects of TFA on model rats of diabetic nephropathy.Results Compared with glipizide group,the level of glycosylated hemoglobin,blood fat,indothelin,urinary microalbumin,BUN,CR,blood viscosity and indexes of renal was decreased,at the same time pathological changes of kidney were alleviated significantly in glipizide plus TFA (50、100 mg ·kg-1,i.g) groups.Conclusion TFA has a remarkable auxiliary therapeutic effect on GK model rats of diabetic nephropathy.%目的 研究黄蜀葵花总黄酮(TFA)联合格列吡嗪对GK糖尿病肾病(DN)模型大鼠有无辅助治疗作用.方法 采用GK大鼠饲喂高脂高蛋白饲料制备DN模型,以糖化血红蛋白、血脂和内皮素水平;血液流变学和肾功能指标;肾脏系数以及肾脏病理组织学为考察指标,全面评价应用格列吡嗪的同时给予TFA对DN模型大鼠的辅助治疗作用.结果 与格列吡嗪组比较,应用格列吡嗪同时给予TFA(50、100 mg· kg-1,ig)可明显降低DN模型大鼠血浆中血脂、内皮素、BUN、CR和尿微量白蛋白水平以及血黏度,可减小肾脏系数,减轻肾脏病理组织学病变.结论 应用降糖药同时给予TFA对DN模型大鼠的肾脏具有明显的保护作用.