AIM To determine the long-term effects of sinoaortic denervation (SAD) on hemodynamics and cardiovascular and renal morphology of rats with normal blood pressure. METHODS Male Sprague-Dawley rats were undertaken SAD. Eighteen weeks after operation, rats were instrumented chronically to record beat-by-beat arterial blood pressure(BP) and heart rate(HR). Computerized data analysis was used to calculate blood pressure variabiity(BPV) and heart rate variability(HRV). Various organs including heart, kidney, spleen and brain of the rats were chosen to examine the morphological changes. RESULTS Eighteen weeks after operation, SAD rats had the same levels of 24-h mean BP as those of sham-operated rats, while BPV of SAD rats were significantly increased when compared with controls. The levels of HR seemed to be higher in SAD rats than controls, but the difference was of no significance, while HRV in SAD rats was markedly decreased when compared with shamoperated rats. After 18 weeks significant organ damage, especially cardiovascular and renal lesion, was found in SAD rats, which was similar to target-organ damage occurred in hypertensive animal models and human essential hypertension. CONCLUSION SAD can lead to cardiovascular and renal morphological changes that are similar to target-organ damage in hypertension.%目的研究去窦弓神经(SAD)对正常血压大鼠的血流动力学及心、肾、血管等器官病理形态学的影响.方法采用SD大鼠施行SAD手术,术后18周行股动脉插管,在清醒、自由活动状态下计算机实时记录24h动脉收缩压、舒张压和心率,并计算血压波动性(BPV)和心率波动性(HRV).处死动物后,取心、脑、肾及脾观察大体及光学显微镜下结构变化.结果SAD术后18周,SAD大鼠的血压和心率水平与假手术组相比无显著差异,但24h BPV明显高于假手术组,HRV明显低于假手术组;大鼠心、肾及血管有明显的类似于高血压靶器官损伤的病理改变.结论SAD可使大鼠的心、肾和血管发生类似于高血压靶器官损伤的病理改变.
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