白细胞介素36(lL-36)包括lL-36α,lL-36β,lL-36γ和 lL-36受体拮抗剂(lL-36Ra)。 lL-36Ra, lL-36α,lL-36β和 lL-36γ曾分别被命名为 lL-1家族成员5,6,8和9,它们均通过lL-1受体相关蛋白2和lL-1受体辅助蛋白介导信号通路。 lL-36Ra 能够阻止 lL-36受体信号的活化。 lL-36参与多种炎症性疾病的发生和发展过程。本文对 lL-36的生物学特征、受体与信号通路、生物学活性及其在银屑病、局限性脱发、关节炎症、肺部炎症及其他炎症性疾病中的作用进行综述。%Cytokines interleukin-36 ( lL-36) has 4 members: lL-36α, lL-36β, lL-36γ and lL-36 receptor agonists ( lL-36Ra). The signal of lL-36Ra, lL-36α, lL-36β and lL-36γ ( formerly lL-1F5, lL-1F6, lL-1F8, and lL-1F9) passes through the lL-1 receptor-related protein 2 and lL-1 receptor-acces-sory protein. lL-36Ra is a receptor antagonist that blocks the activation of lL-36 receptor signaling. lL-36 plays a significant role in the pathogenesis of several inflammatory diseases. This review introduces the biological characteristics, receptor and signal pathway, biological activity of lL-36 cytokines and their roles in the pathogenesis of a wide variety of inflammatory diseases.
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