量子点作为一种新型荧光纳米材料而具有广泛的应用前景,所以量子点暴露所引起的毒性以及生物安全问题逐渐引起人们的重视.本文简单介绍了量子点在生物医学领域的应用,着重介绍了量子点的毒性作用和毒作用机制.整体水平上的毒性作用如对消化系统、呼吸系统、生殖系统及中枢神经系统的损伤,细胞水平上的毒性作用如对MRC-5细胞的毒性作用、对原代培养的大鼠海马神经元的毒性作用和对L929细胞的毒性作用等.量子点的毒性作用机制主要有氧化应激损伤及活性氧产生的毒性、炎症反应损伤、免疫毒性和材料本身的固有毒性等.%Quantum dots (QDs), as novel fluorescent nanotechnology products, have broad appli?cation prospects. However, more attation is paid to the toxicity and bio-safety of QDs because of QDs' exposure. This article introduces the application of QDs in bio-medicine in general and the toxic effects and toxicity mechanisms of QDs in particular. The overall toxic effects involve not only different systems (the digestive system, respiratory system, reproductive system and nervous system), but also different cells (MRC-5 cells, hippocampal neurons and L929 cells) at the cellular level. The toxicity mechanisms of QDs are also reviewed, including oxidative stress, generation of ROS, inflammation, immunotoxicity and toxicity of synthetic materials of QDs.
展开▼
