AIM: To explore whether vasculogenic mimicry (VM) exists in human epithelial ovarian cancer ( EOC) , and to elucidate the relationship between E - cadherin ( E - cad) expression and VM. METHODS: The E - cad expression and VM in 80 specimens of EOC and 20 specimens of benign ovarian epithelial tumor tissues were detected by the methods of immunohistochemical and histochemical staining. RESULTS: The positive rates of VM and E - cad protein in EOC were 57.4% and 48.7% , respectively. The positive rates of VM and E - cad protein in benign epithelial tumor tissues were 0% and 75. 0% , respectively. There was a significant difference between the two groups ( P < 0. 05 or P < 0.01). The E-cad expression and VM in EOC was significantly related to differentiation, metastasis to abdominal organ and lymphnode, and PTNM stage ( P < 0.05 ). A negative relationship between the expression of E - cad and VM (r =0.578,P<0. 01) was also observed. PTNM stage, metastasis to abdominal organ and lymphnode, the expression of Ecad and VM were independent prognosis factors of EOC patients after total correction ( P < 0. 05 ). The five - year survival rate between VM - positive group and VM - negative group was significantly different (4.3% vs 88.2% ), while the fiveyear survival rate was significantly lower in E - cad - negative group than that in E - cad - positive group (9. 8% vs 71. 8% ). CONCLUSION: EOC with VM has a poor differentiation and a bad clinical prognosis. The levels of VM and E - cad correlate with the progression and prognosis of EOC.%目的:探讨血管生成拟态 (vasculogenic mimicry,VM)与E-钙黏蛋白(E-cadherin,E-cad)在人卵巢上皮癌(epithelial ovarian cancer,EOC) 组织中的表达及意义.方法:收集80例EOC标本和20例卵巢良性上皮性肿瘤标本,应用免疫组化法和组织化学法检测EOC和卵巢良性上皮性肿瘤组织中VM和E-cad的表达情况.结果:在EOC和卵巢良性上皮性肿瘤组织中,VM和E-cad的阳性表达率分别为57.4%、0%和48.7%、75.0%,差异均显著(P＜0.05或P<0.01);VM及E-cad的表达与EOC的组织学分级、腹腔脏器及淋巴结转移以及临床PTNM分期有关(P＜0.05);VM与E-cad在EOC中的表达呈负相关(r=-0.578,P＜0.01).多因素分析:PTNM分期、腹腔脏器及淋巴结转移、VM和E-cad的表达是影响EOC根治术后患者预后的独立因素(P＜0.05);VM阳性组与阴性组的5年生存率分别为4.3%和88.2%,E-cad阳性组与阴性组的5年生存率分别为71.8%和9.8%,差异均显著(P＜0.05).结论:具有VM的EOC组织分化低,患者临床预后差;VM与E-cad的表达水平与EOC的发展及预后有一定的关系.
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