目的：分析入院拟手术的慢性化脓性中耳炎患者耳部感染的菌群分布及药敏结果，寻找敏感的抗生素，指导临床合理用药。方法81例诊断慢性化脓性中耳炎入院拟行手术的患者耳道分泌物进行细菌培养及药敏试验，对培养阳性菌株的种类以及药物敏感试验结果进行统计分析。结果81份标本中分离出致病菌43株，阳性率53％，革兰氏阳性球菌24株（55．8％），以金黄色葡萄球菌及星座链球菌为主；革兰氏阴性杆菌17株（39．5％），以铜绿假单胞菌，肺炎克雷伯菌，大肠埃希菌为主，真菌2株（4．6％）。革兰氏阳性菌普遍对碳青霉烯，万古霉素类抗生素敏感，革兰氏阴性菌普遍对莫西沙星，碳氢霉烯类，万古霉素等抗生素敏感，结论革兰氏阳性菌是本地区慢性化脓性中耳炎的主要致病菌，临床需根据药敏结果选择安全有效的药物治疗。%Objective Analysis of the distribution of pathogenic bacteria and its drug sensitivity of chronic suppurative otitis media in patients to be operated ,searching for sensitive antibiotics and guiding clinical rational drug use .Methods The bacterial culture and drug sensitivity test were carried out on the patient's ear canal secretion with chronic suppurative otitis media admitted to be treated with surgery ,and the type of positive strains and drug sensitivity test results were statistically analyzed .the results were statisticallyanalyzed.Results 43strainspathogenicbacteriaweredetectedin81samples,andthepositive rate was 53% .Gram positive bacteria were 24 (55 .8% ) ,mainly staphylococcus aureus and streptococcus constellation ;.gram negative bacilli were 17 (39 .5% ) ,mainly pseudomonas aeruginosa ,klebsiella pneumoniae ,escherichia coli;Fungi were 2 strains (4 .6% ) .Gram positive bacteria were sensitivated to carbapenems and vancomycin ,while gram negative bacteria generally to moxifloxacin ,carbapenems and vancomycin .Conclusion Gram positive bacteria are the main pathogens of chronic suppurative otitis media in the local area .We need to choose safe and effective drug treatment according to drug sensitive test .
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