甘桔冰梅片防治急性咽炎的主要药效学研究

摘要

Objective To investigate the major pharmacodynamics effects of Ganju Bingmei Tablets (GJBMT) on the prevention and treatment of acute pharyngittis based on an experimental study. Methods Model of acute pharyngittis was prepared with rats by the method of pharyngeal painting with capsicin. Then, GJBMT was given to these rats with experimental acute pharyngittis at various dosages to observe its therapeutic effect on the lesion in the pharyngx. At the same time, its inhibitory effect on infecting bacteria was also investigated experimentally. Results Animals in all groups with various levels of dosages showed significantly therapeutic effect on kind of acute pharyngeal inflammatory reaction, such as to alleviate epithelial damage, hyperemia, tissue edema and inflammatory cell infiltration, with statistically significance when compared with that of modeling group (P<0.05), especially in the groups with either dosages of 2.66g/kg or 5.32 g/kg. Meanwhile, GJBMT showed some inhibitory effect on Staphylococcus aureus and beta hemolytic streptococcus. Conclusion Ganju Bingmei Tablets hold significant therapeutic effect on acute pharyngittis of rats to alleviate inflammatory reaction pharyngeal mucosa, and can give rise inhibitory effect on the growth of bacteria at a certain level.%目的评价甘桔冰梅片防治急性咽炎的主要药效学作用。方法局部涂抹辣椒素复制大鼠急性咽炎模型，然后分别应用不同剂量甘桔冰梅片进行治疗，观察其疗效及抑菌效应。结果甘桔冰梅片各剂量组均可显著减轻模型大鼠咽部黏膜上皮损伤、充血、水肿及炎细胞浸润等急性炎症反应，与模型组比较，均有统计学意义，尤以2.66g/kg和5.32 g/kg剂量组效果更为明显。同时，甘桔冰梅片还对金黄色葡萄糖球菌及乙型溶血性链球菌的生长具有一定的抑制效应。结论甘桔冰梅片可显著减轻急性咽炎大鼠的炎症反应，并具有一定的抑菌作用。