变应性鼻炎治疗新策略

摘要

Allergic rhinitis (AR) is a nasal inflammatory,IgE-mediated disease that occurs when some individuals inhales something he or she is allergic to,such as pollen or animal dander.It is also a refractory disease with high prevalence in the field of rhinology.The treatment of AR is really a difficult and challenging task because of the high prevalence,economic burden and the interference to the quality of life.At present,nasal corticosteroid and antihistamines were the mainly therapies,however,there is up to 40％ patients not satisfactory to these therapies.So exploring new therapy or target is necessary.This article will review the results of previous studies focused on the new therapies of AR.%变应性鼻炎(allergic rhinitis,AR)是机体吸入变应原后主要由IgE介导的鼻黏膜非感染性炎性疾病,是鼻科领域高患病率的难治性疾病.随着患病率的逐年增高,AR引起了一系列社会问题,包括对患者生活质量的影响、对工作、学习的干扰以及经济负担的逐渐加重.目前,AR的治疗任务及难度都面临着巨大的挑战,临床常用鼻用糖皮质激素和抗组胺药物控制鼻部症状,然而有研究显示,对疗效不满意的患者约高达40％.因而AR的治疗仍迫切需要开拓思路,探索新的有效治疗方法.本文对治疗AR新方法的临床研究进行综述.