目的 观察2型糖尿病(T2DM)患者骨质疏松与25羟维生素D3(25-OH-D3)的关系.方法 测定186例2型糖尿病(T2DM)患者及65例年龄、性别相匹配健康对照者血(Ca) 、磷(P),采用酶联免疫法测定各组血清骨特异性碱性磷酸酶(ALP)、血清骨钙素(BGP)、(25-OH-D3)的浓度.结果 2型糖尿病组BGP、25-OH-D3浓度低于对照组,差异显著(P<0.05),血清Ca、P、血浆ALP浓度与对照组之间无显著差异(P>0.05).女型糖尿病患者骨质疏松症的发病率高于男性,女性OP组BGP、25-OH-D3的浓度显著低于男性OP组(P<0.05).结论 2型糖尿病患者25-OH-D3的减少可影响钙、磷代谢,从而导致骨质疏松,因此对于2型糖尿病患者应早期适量补充钙剂及维生素D3.%Objective To explore the relationship between osteoporosis and 25-OH^vitamin D3in patients with type 2 diabetes (T2DM). Methods A total of 186 patients with T2DM and 65 healthy volunteers, who were age-and gender -matched, were enrolled. Serum concentrations of Ca and P in both groups were measured. Serum concentrations of bone Gla protein (BGP) , alkaline phosphatase (ALP) , and 25-OH-vitmin D3 were measured using ELISA method. Results BGP and 25-OH-vitmin D3 in T2DM group were lower than those in control group , and the difference was significant (P <0. 05). The concentrations of Ca , P, and ALP had no significant difference compared to those in the control group (P >0. 05). The incidence of osteoporosis in female diabetic patients was higher than that in male diabetic patients . The concentrations of BGP and 25-OH-vitamin D3 in female patients with osteoporosis were significant lower than those in male patients with osteoporosis (P < 0. 05). Conclusion The decrease of 25-OH^vitmin D3 in patients with T2DM impacts the metabolism of calcium and phosphate , which can lead to osteoporosis. So a proper supplementation of calcium and vitamin D 3 at an early stage is very important for patients with T 2DM.
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