抗CCP抗体在类风湿性关节炎诊断中的应用进展

摘要

目前类风湿关节炎的诊断检查有炎性标志物（包括血沉和C反应蛋白）检测，免疫复合物和补体检测，关节滑液检测以及自身抗体检测。这些指标经常伴随类风湿关节炎的活动而改变，早期诊断主要依靠的是自身抗体检测。抗环瓜氨酸肽（ cyclic citrullinated peptide，CCP）抗体是一种抗角蛋白抗体，在类风湿性关节炎的敏感度和特异度较类风湿因子高。发病一年内，类风湿性关节炎患者大部分血清中可检测到抗CCP抗体的存在，同时抗CCP抗体阳性也可以用来预测严重破坏的类风湿性关节炎。因此，抗CCP抗体对于类风湿性关节炎的早期诊断及预后评估是极有帮助的。本文综述了近年来抗CCP抗体对于诊断类风湿关节炎的应用进展。%Currently the markers for the diagnosis of rheumatoid arthritis include inflammatory makers ( including blood sedimentation and C-reactive protein) , immune complexe and complement detection, detection of joint synovial fluid, and detection of autoantibodies.These indicators change with the activity of arthritis.Early diagnosis relies mainly on detection of autoantibodies. Anti-cyclic citrullinated peptide antibody( anti-CCP) is a kind of anti-keratin antibody, having higher sensitivity and specificity than the rheumatoid factor in diagnosis of rheumatoid arthritis.During the first year of rheumatoid arthritis, the existence of anti-CCP can be detected in the serum of most of these people.Positive anti-CCP can also be used to predict serious damage.Therefore, anti-CCP is extremely helpful in early diagnosis and prognosis assessment of rheumatoid arthritis.In this paper, the recent application of anti-CCP in the diagnosis of rheumatoid arthritis is reviewed.