Lack of response to classic treatment is associated with anti-cyclic citrullinated peptide antibodies but not with drb1-se status in patients with recent-onset rheumatoid arthritis

摘要

Introduction: It is known the relationship between DRB1-SE(+) alleles, antiCCP antibodies and RF and the most severe forms of RA. Therefore our objective was to evaluate these aspects in patients did not respond to treatment with DMARDS. Patients and methods: We studied 153 patients (42 non-responses to classical DMARDs). Results: In the non-responsive patients we found a higher frequency of antiCCP antibodies (p=0.03; OR=3.79) and DRB1*0405 allele (p=0.012; OR=6.31. However, the logistic regression analysis associated non-responsiveness to classical DMARDs solely with the presence of antiCCP antibodies (p=0.025; OR 3.17). Conclusions: The presence of antiCCP antibodies is associated to non-responsiveness to the initial treatment with classical DMARDs.