synthetic peptide, methods for detecting an anti-citrullinated protein antibody in a biological sample, for performing an assay to aid in the diagnosis or prognosis of rheumatoid arthritis, to improve the sensitivity of diagnosing or predicting rheumatoid arthritis, an assay to diagnose or predict rheumatoid arthritis , kit, and method for identifying a peptide that is immunologically reactive with an anti-citrullinated protein antibody

摘要

The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.