降钙素基因相关肽对骨质疏松症骨组织及胃肠作用的研究进展

摘要

现代研究发现，腰椎椎体含有丰富的降钙素基因相关肽（ calcitonin gene⁃related peptide，CGRP）阳性神经纤维，CGRP可作用于破骨细胞，抑制骨质吸收；还能作用于成骨细胞，促进骨质形成。 CGRP在胃肠道内广泛分布，CGRP与受体结合对胃肠运动起抑制作用，CGRP含量过高可能是骨质疏松症患者便秘并发症的一个病因。对骨质疏松症患者早期进行便秘防治干预，可减轻骨质疏松症患者的痛苦，促进骨质疏松症的康复有重要作用。骨质疏松症患者腰椎骨密度的变化、血浆CGRP的含量与便秘程度的关系还有待于进一步研究。%Current research has found that lumbar vertebral body contains abundant calcitonin gene related peptide ( CGRP ) positive nerve fibers. CGRP acts on osteoclasts and inhibits bone resorption. It also acts on osteoblasts and promotes bone formation. CGRP is widely distributed in the gastrointestinal tract. CGRP inhibits gastrointestinal motility when binds to its receptor. Excessive CGRP may be a cause of constipation in patients with osteoporosis. Prevention and treatment of constipation as early intervention in patients with osteoporosis can relieve the pain and promote the rehabilitation of osteoporosis. The relationship between CGRP and constipation and lumbar bone mineral density in patients with osteoporosis needs further study.