妊娠期糖尿病对初次妊娠及再次妊娠骨密度的影响

摘要

目的 研究妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇初次妊娠和再次妊娠的骨密度(body mineral density,BMD)情况.方法 回顾性病例分析,入组单胎经产妇200人,其中100人初次妊娠诊断GDM,为GDM组,另100人初次妊娠血糖正常,为对照组.查询所有孕妇初次妊娠早孕期超声骨密度结果,产褥期骨密度情况,及再次妊娠早孕期骨密度情况.结果 初次妊娠GDM组早孕期BMD与对照组无统计学差异(P＞0.05),产褥期BMD与对照组无统计学差异(P＞0.05),再次妊娠GDM组早孕期BMD与对照组无统计学差异(P＞0.05).GDM产妇初次妊娠产褥期BMD与早孕期相比下降,差异有统计学意义(P＜0.05),而对照组初次妊娠产褥期BMD与早孕期相比无统计学差异(P＞0.05).结论 GDM引起孕期骨密度下降,应加强管理,减少骨质疏松的发生.%Objective To investigate the influence of gestational diabetes mellitus GDM) on bone mineral density (BMD) in primigravida and multipara.Methods Retrospective case analysis of 200 single birth multipara,who were divided into two groups:the GDM group had 100 women who were diagnosed GDM in primigravida,while the control group had 100 women with normal blood glucose in primigravida.All the pregnant women had BMD measured using ultrasound bone densitometer at early pregnancy and puerperium in primigravida and at early pregnancy in multipara.Results The two groups' early pregnancy and puerperium BMD in primigravida had no significant difference.The two groups' early pregnancy BMD in multipara had no significant difference.GDM group's puerperium BMD was lower than early pregnancy BMD,and the difference had statistical significance.The control group's puerperium BMD was not significantly different from their early pregnancy BMD.Conclusion GDM may cause a decline of BMD,and we should strengthen management to prevent the incidence of osteoporosis.