剥脱性开角型青光眼与原发性开角型青光眼眼前节结构参数的比较

摘要

Objective:To analyze and compare the differences of anterior segment structure parameters between pseudoexfoliation open angle glaucoma (PXOAG) and primary open angle glaucoma (POAG).Methods:This clinical case control study was conducted from December 2012 to December 2016,and the patients were selected consecutively.The PXOAG group included 54 eyes of 54 cases with an average intraocular pressure of 28.8±7.9 mmHg.The POAG group included 53 eyes of 53 cases that were matched for age,gender,and intraocular pressure,26.3±7.4 mmHg.Anterior segment structure parameters such as corneal thickness,corneal endothelial cell density,hexagonality,anterior chamber depth,and lens thickness were measured and analyzed using independent samples t-tests.Results:For the PXOAG group,the central corneal thickness (523±41 μμn),hexagonality (52％--±14％),anterior chamber depth (2.79-±0.60 mm),and lens thickness (4.98±0.42 mm) were not significantly different from the POAG group (t=1.57,0.18,i.11,0.26,respectively,P＞0.05 each).However,the corneal endothelial cell density of the PXOAG group (2 323±451/mm2) was significantly lower than that of the POAG group (2 538±356/mm2;t=2.78,P=0.01).Conclusions:The corneal endothelial cell density of POXG patients is lower than that of POAG patients.This is a reminder to pay more attention to the protection of corneal endothelial cells during clinical treatment.%目的:比较剥脱性开角型青光眼(PXOAG)与原发性开角型青光眼(POAG)眼前节结构参数的差异.方法:病例对照研究.选取2012年12月至2016年12月住院治疗的连续PXOAG病例54例(54眼)作为PXOAG组,平均眼压为(28.8±7.9)mmHg(1 mmHg=0.133 kPa).选取性别、年龄及眼压相匹配的POAG病例53例(53眼)作为POAG组,平均眼压为(26.3±7.4) mmHg.测定2组患者角膜厚度、角膜内皮细胞密度、六角型细胞比例、前房深度及晶状体厚度等眼前节参数,并采用独立样本t检验进行数据分析.结果:POAG组角膜厚度、角膜内皮细胞密度、六角型细胞比例、前房深度及晶状体厚度分别为(535±36) μm、(2 538±356)/mm2、(52±12)％、(2.89±0.36) mm和(4.96±0.41)mm;PXOAG组相应参数分别为(523±41) μm、(2 323±451)/mm2、(52±14)％、(2.79±0.60)mm和(4.98±0.42)mm.2组患者角膜厚度、六角型细胞比例、前房深度及晶状体厚度比较差异无统计学意义(t=1.57、0.18、1.11、0.26,P＞0.05),而角膜内皮细胞密度比较差异有统计学意义(t=2.78,P=0.01).结论:PXOAG与POAG相比,角膜内皮细胞密度较低,提示在临床治疗过程中应更加注意对角膜内皮的保护.