早中期阿尔茨海默病患者黄斑区脉络膜厚度变化临床观察

摘要

目的 观察早中期阿尔茨海默病(AD)患者黄斑区脉络膜厚度(CT)变化.方法 成组设计的临床病例对照研究.2016年11月至2018年6月于金华市中心医院神经内科首次诊断的早中期AD患者21例(AD组)和健康志愿者21名(正常对照组)纳入研究.两组受检者平均年龄(t=0.128)、眼压(t=0.440)、眼轴长度(t=1.202)比较,差异无统计学意义(P＞0.05);简易智能精神状态检查量表评分比较,差异有统计学意义(t=8.608,P＜0.05).采用频域OCT增强深度成像技术测量受检眼黄斑中心凹CT(SFCT)以及距离中心凹0.5、1.0 mm范围内鼻侧(NCT05,10mm)、颞侧(TCT05,10mm)、上方(SCT0.5,10mm)、下方(ICT0.5,1.0mm)CT.组间上述指标较采用两独立样本t检验.结果 与正常对照组受检眼比较,AD组受检眼SFCT (t=2.431)、NCT0.5,1.0mm(t=3.341、2.640)、TCT0.51.0mm(t=3.340、2.899)、SCT0.5.1.0mm(t=3.576、3.751)、ICT0.5,1.0mm(t=2.897、2.903)均变薄,差异均有统计学意义(P＜0.05).结论 与正常同龄人比较,早中期AD患者黄斑区CT显著变薄.%Objective To obverse the changes ofmacular choroidal thickness (CT) in patients with mild to moderate Alzheimer's disease (AD).Methods This was a case-control study.Twenty-one patients with mild to moderate AD confirmed by Neurology Department of Jinhua Central Hospital from November 2016 to June 2018 and 21 age-matched control subjects were concluded in the study.There was no significant difference in age (t=0.128),intraocular pressure (t=0.440) and axial length (t=1.202) between the two groups (P＞0.05).There was significant difference in mini-mental state examination score (t=8.608,P＜0.05).CT was measured by OCT with enhanced depth imaging technique in the subfoveal choroid,at 0.5 mm and 1.0 mm from the center of the fovea nasal (NCT0.5,1.0mm),temporal (TCT0.5,1.0mm),superior (SCT0.5,1.0mm),and inferior (ICT0.5,1.0mm).Independent-samples t test was used to compare the results obtained from these two groups.Results SFCT (t=2.431),NCT0.5,1.0 mm (t=3.341,2.640),TCT0.5,1.0 mm (t=3.340,2.899),SCT0.5.1.0 mm (t=3.576,3.751) and ICT0.5 (t=2.897,2.903) were significantly thinner in AD eyes than those in control eyes.Conclusion Compared with healthy subjects,patients with mild to moderate AD showed a significant reduction in CT.