Objective To Explore the relationship between HPV infection and bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomonal vaginitis (TV). Methods Clinical data from 1 261 gynecologic outpatients who underwent the vaginal microecology and HPV type detection during June 2015 to December 2015 were collected and analyzed in the First Affiliated Hospital of Xi′an Jiaotong University. Results In 1 261 patients, 328 cases infected with HPV, infection rate was 26.01%(328/1 261);vaginal infectious disease in 328 cases of HPV infections were 219 cases (66.8%, 219/328), vaginal infectious diseases in 933 cases of HPV uninfected were 503 cases (53.9%, 503/933), incidence of vaginal infectious disease in HPV infected patients was higher than that in HPV uninfected patients (χ2=5.87, P=0.01). 142 cases of BV had 54 cases infected with HPV (38.0%, 54/142), 296 cases of intermediate type BV had 88 cases infected with HPV (29.7%, 88/296), 231 cases of normal vaginal microecology had 51 cases infected with HPV (22.1%, 51/231), 99 cases of VVC had 15 cases infected with HPV (15.2%, 15/99), 2 patients with TV had 0 cases infected with HPV (0/2), HPV infection rate in BV, intermediate type BV patients were significantly higher than normal patients (P<0.05), while there were no statistical differences among VVC, TV and normal patients (P>0.05). The intensity of HPV infection were positively correlated with BV, intermediate type BV (OR=2.17, 95%CI: 1.37-3.43, P<0.01; OR=1.49, 95%CI: 1.00-2.22, P=0.04);while, VVC, TV were uncorrelated with HPV infection (all P>0.05). Conclusions BV, intermediate type BV are positively correlated with HPV infection, especially for the high-risk HPV. VVC and TV are not correlated with HPV infection.%目的探讨HPV感染与细菌性阴道病（BV）、外阴阴道假丝酵母菌病（VVC）、滴虫性阴道炎（TV）的相关性。方法收集2015年6—12月就诊于西安交通大学第一附属医院妇科门诊，同时检测阴道微生态及HPV分型的1261例患者的临床资料并进行分析。结果1261例患者中，HPV感染者328例，HPV感染率26.01%（328/1261）；328例HPV感染者中，患阴道感染性疾病者219例（66.8%，219/328），933例未感染HPV者中，患阴道感染性疾病者503例（53.9%，503/933），HPV感染者较未感染者患阴道感染性疾病的发生率高（χ2=5.87，P=0.01）。142例BV患者中感染HPV者54例（38.0%，54/142），296例中间型BV患者中感染HPV者88例（29.7%，88/296），231例阴道微生态正常者中感染HPV者51例（22.1%，51/231），99例VVC患者中感染HPV者15例（15.2%，15/99），2例TV患者中感染HPV者0例（0/2）；BV、中间型BV患者与阴道微生态正常者之间HPV感染率差异有统计学意义（P<0.05），VVC、TV患者与阴道微生态正常者之间HPV感染率差异无统计学意义（P>0.05）。BV、中间型BV与HPV感染呈正相关（OR=2.17，95%CI为1.37~3.43，P<0.01；OR=1.49，95%CI为1.00~2.22， P=0.04），VVC、TV与HPV感染无相关性（P>0.05）。结论 BV与HPV感染，尤其是与高危型HPV感染呈正相关，而VVC、TV与HPV感染无关。
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