目的:应用动态心电图评价依帕司他对糖尿病患者心率变异性的影响,确认依帕司他治疗糖尿病心脏自主神经病变的疗效.方法:收集糖尿病合并心脏自主神经病变患者100例,分为治疗组和对照组,治疗组患者口服依帕司他50 mg,tid,共8周.运用24 h动态心电图检测所有患者在治疗前后心率变异性指标的变化,观察依帕司他治疗糖尿病心脏自主神经病变的疗效.结果:治疗组心率变异性各项指标治疗2个疗程后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义.结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可改善患者心率变异性.%Objective; To evaluate the effect of epalrestat on heart rate variability in diabetic patients. Methods; Totally 100 diabetic patients with cardiac autonmic neuropathy were analyzed. The patients were treated with 50 mg epalrestat, 3 times a day for 8 weeks. The heart rate variability ( HRV) in all patients was monitored with a 24-h holter. Results; The indexes of HRV were significant improved after 8-week treatment. Conclusion; Epalrestat can improve HRV in diabetic patients, and it is an effective treatment of cardiac autonmic neuropathy.
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