目的:观察长期应用来氟米特治疗类风湿关节炎(类风关)的疗效和不良反应.方法:21例类风关病人[男性2例,女性19例;年龄(45±s9)a;病程(59 ±48)mo],首先应用来氟米特20 mg,po,qd进行为期0.5 a的双盲、单盲试验,以后又继续按原剂量用药并随访,其中有9例服药6 mo至1 a后改用10 mg,po, qd.结果:21例随访1.5 a(包括双盲、单盲试验的6 mo,下同),临床缓解1例,显效20例;19例随访2 a, 临床缓解7例,显效12例;17例随访2.5 a,临床缓解10例,显效7例;12例随访3 a,临床缓解9例,显效3例.X线双手正位片3 a随访中无变化6例.先后发生不良反应共计为19 %(4/ 2 1例).结论:来氟米特长期治疗类风关疗效好、不良反应少.%AIM: To investigate the efficacy and safety of leflunomide (Lef) in long-term treatm ent of rheumatoid arthritis (RA). METHODS: Twenty-one patients ［M 2,F 19; age (45±s 9)a］ with RA were s elected. Disease duration was (59±48) mo. All patients enrolled in double-blin d or single-blind trials with Lef 20 mg, po, qd for 6 mo at first. Doses of leflunomide in nine patients were reduced down to 10 mg, qd and all the others c ontinued the treatment with Lef at 20 mg, qd. RESULTS: All twenty-one patient s we re followed up for 1.5 a. The results showed that twenty patients had remarkable improvement and one patient had clinical remission. Ni neteen patients had been followed up for more than 2 a and twelve patients had r emarkable improvement while seven patients had clinical remission. Twelve pati ents had been followed up for 3 a and three of them had remarkable improvement while nine patients had clinical remission. Total rate of adverse reactions was 19 %( 4/21). CONCLUSION: This study shows that long-term treatment of RA with Lef is effec tive and safe.
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