布洛芬缓释胶囊内服配合中药外敷治疗膝骨性关节炎40例疗效观察

摘要

Objective To observe the clinical efficacy of oral ibuprofen sustained-release capsules combined with external application of Chinese medicine in the treatment of knee osteoarthritis.Methods Forty patients with knee osteoarthritis as the observation group and treated by oral ibuprofen sustained-release capsules combined with ex-ternal application of Chinese medicine.Forty cases in the control group were treated with oral ibuprofen sustained-re-lease capsules,10 days were used as a course of treatment.Results In the treatment group, 5 cases were cured, 20 cases were marked effective, 12 cases were effective and 3 cases were ineffective.In control group, 2 cases were cured, 13 cases were marked effective, 16 cases were effective and 9 cases were ineffective.The therapeutic effect of the observation group was better than that of the control group( P<0.05) .Compared with the scores before and after treatment, the scores in pain, walking distance, joints function, swelling and activity of daily living all decreased sig-nificantly in two groups, but the therapeutic effect of the observation group was better than that of the control group(P<0.05).Conclusion Ibuprofen sustained-release capsules combined with external application of Chinese medicine in the treatment of knee osteoarthritis has significant clinical efficacy and safety.It is worthy of clinical application.%目的：观察布洛芬缓释胶囊内服结合中药外敷治疗膝骨性关节炎的临床疗效。方法将80例膝骨性关节炎患者按就诊单双号分为两组。对照组40例口服布洛芬缓释胶囊治疗，治疗组40例在对照组的基础上加用中药外敷治疗，10 d为1个疗程。结果治疗组临床治愈5例，显效20例，有效12例，无效3例，对照组分别为2、13、16、9例。两组疗效比较差异有统计学意义（ P＜0．05）。治疗后两组患者膝关节疼痛、最大步行距离、关节功能、日常活动能力、关节肿胀等指标评分均较治疗前显著下降，差异均有统计学意义（ P＜0．05）。治疗组各项评分均低于对照组，差异均有统计学意义（ P＜0．05）。结论布洛芬缓释胶囊内服结合中药外敷治疗膝关节骨性关节炎安全有效。