特发性膜性肾病外周血淋巴细胞亚群的免疫学研究进展

摘要

膜性肾病是成人肾病综合征常见的病因之一，发病率逐年升高。膜性肾病从本质上来说属于自身免疫性疾病，其公认机制为T淋巴细胞刺激B淋巴细胞的增殖和激活，导致免疫复合物形成并沉积于肾小球基底膜上皮细胞下。外周血淋巴细胞亚群为近年的研究热点，该文从T细胞亚群和B淋巴细胞两个方面阐述特发性膜性肾病免疫学研究的新进展，为其防治提供新的靶点。%Membranous nephropathy is one of the common causes of adult nephritic syndrome , and its inci-dence has been on the rise significantly .As a kind of autoimmune disease , membranous nephropathy is generally rec-ognized to be caused by the deposition of immune complex formation under the glomerular basement membrane epithe -lium as a result of B lymphocyte proliferation and activation stimulated by T lymphocytes , but its specifical pathogene-sis remains unclear .Peripheral blood lymphocyte subsets become a research hotspot in recent years .This paper aims to highlight the immunological research advances of T lymphocyte subsets and B lymphocytes in idiopathicmembranous nephropathy , so as to provide a novel target for the prevention and treatment of idiopathic membranous nephropathy .