目的：对来宾市新生儿α-地中海贫血情况进行筛查，为来宾市α-地中海贫血的临床诊断及防治提供参考依据。方法收集2014-05～2015-04该院住院分娩的2050例新生儿脐带血标本，采用琼脂糖凝胶电泳测定HbBart′s含量，分析新生儿α-地中海贫血的发生情况。结果2050例新生儿中共检出α-地中海贫血272例，阳性率为13.27％，其中静止型137例（50.37％），标准型129例（47.43％），HbH 6例（2.20％）。结论利用琼脂糖凝胶电泳能快速、有效筛查新生儿α-地中海贫血。来宾市为α-地中海贫血高发区，需积极开展α-地中海贫血防治工作，提高出生人口素质。%Objective To screen for α-thalassemia in the neonates in Laibin city , and to provide the evi-dence for the clinical diagnosis , prevention and treatment of the disease .Methods Umbilical cord blood was collect-ed from 2 050 neonates in our hospital from May 2014 to April 2015 .The HbBart′s contents of the neonates were de-terminated by the agarose gel electrophoresis .The incidence of neonates with α-thalassemia was calculated .Results Two hundrend and seventy-two cases withα-thalassemia were checked out from 2 050 neonates .The positive rate was 13.27%, of which 137 cases(accounting for 50.37%) with static type,129 cases(accounting for 47.43%) with standard type, and 6 cases(accounting for 2.21%) with Hemoglobin H disease.Conclusion The agarose gel elec-trophoresis is an efficient method fror quickly screening out α-thalassemis in neonates .Laibin city is an area with a high incidence of α-thalassemia.Active prevention and controlling measures should improve the population quality in this area.
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