阿立哌唑与氟哌啶醇治疗儿童抽动障碍的对照研究

摘要

Objective To evaluate the efficacy and tolerability of Aripiprazole and Haloperidol treatment in children with tic disorders. Methods Sixty-eight children of 5 - 16 years old with tic disorder were randomly assigned to Aripiprazole group (5 ~ 20 mg/d) and Haloperidol group (2-8 mg/d). Treatment efficacy and tolerability was measured using the Yale Global Tic Severity Scale (YGTSS) and the Treatment Emergent Symptom Scale (TESS) at the baseline, week 2 and 4, and 8, respectively. Results Total tic scores as measured by the YGTSS decreased over time in the both groups. The overall rates of effectiveness after 8 weeks treatment were 79% and 73% at week 8 in Aripiprazole group (5 ~ 20 mg/d) and Haloperidol group (2-8 mg/d) , respectively (χ2 = 0.354, P> 0.05). TESS scores [(2.53 ± 2.95) vs. (12.26 ± 10.58), (1.95 ± 2.06) vs. (7.58 ± 5.26), (1.36 ± 1.85) vs. (4.68 ± 2.06) ] were significantly lower in in the Aripiprazole group than in the haloperidol group at week 2 4 and 8 after treatment. Conclusions Aripiprazole may be a promising drug in the treatment among children with tic disorders because of its high efficacy and less tolerability.%目的 比较阿立哌唑与氟哌啶醇治疗儿童抽动障碍的疗效和安全性.方法 将68 例5 ～ 16 岁抽动障碍患儿随机分为两组,每组34 例,分别给予阿立哌唑(5 ～ 20 mg / d)与氟哌啶醇(2 ～ 8 mg / d)治疗,采用耶鲁综合抽动严重程度量表(Yale Global Tic Severity Scale,YGTSS)、副反应量表(treatment emergent symptomscale,TESS)于治疗前、治疗第2、4、8 周末评估疗效和安全性.结果 从治疗第2 周末起阿立哌唑组和氟哌啶醇组YGTSS 总分均下降,减分率无明显差异,治疗8 周后,阿立哌唑组和氟哌啶醇组治疗总体有效率分别为79%和73%,差异无统计学意义.而在2,4,8 周阿立哌唑组TESS 分[(2.53 ± 2.95) vs.(12.26 ± 10.58),(1.95 ± 2.06) vs.(7.58 ± 5.26),(1.36 ± 1.85) vs.(4.68 ± 2.06)]明显低于氟哌啶醇组,均P﹤0.05.结论 阿立哌唑能有效改善儿童抽动障碍,疗效与氟哌啶醇相当,而且副反应小,适合儿童治疗.