The influence of antipsychotic drug haloperidol on repolarization defined by QTc interval was analyzed in electrograms of 8 isolated guinea pig hearts. Each experiment consisted of four phases: stabilization (S), first haloperidol administration (H1), washout (W), and second haloperidol administration (H2). QTc was computed according to three correction models: Bazett's, Fridericia's and dynamic model based on transfer function (TRF). Mean value and standard deviation of QTc were assigned from the interval of 2000 beats in the middle of all four experimental phases.
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