母婴分离常常被用来模拟人类早期应激,但它对个体的负面影响能否被长期正常的生活经历所逆转仍然未知.本研究考察了母婴分离猕猴经历了长期的正常社会生活之后的HPA轴功能和行为.结果发现,母婴分离猴的HPA轴功能紊乱,行为异常,尤其是反映焦虑状态的行为大大增加.从而第一次在猕猴中证明,母婴分离的影响是长期和持久的.同时也说明母婴分离猕猴是人类早期应激的理想动物模型,可以用来研究早期应激诱发的某些精神疾病的发生和发展.%For rhesus monkeys, maternal separation (MS) is often used to mimic childhood adversity in humans, which can lead to brain dysfunction and, as results, behavioral abnormalities. People who suffer from psychiatric disorders due to childhood adversity usually lived a normal social life prior to the onset of the diseases. Instead, the effects of MS on rodents could be reversed by later experience. In order to identify whether the adverse effects of MS were reversible by later normal social living in rhesus monkeys, we conducted a long-term study and established an animal model for human early adversity in rhesus monkeys. The results showed that MS lead to dysfunction of HPA axis which helps manage stress and resulted abnormal behaviors in these rhesus monkeys. Furthermore, the normal social life appeared not to have obliterated the imprints of MS, suggesting that the effects of MS are long-lasting. Thus, compared to rodent models of MS, the maternal separated rhesus monkeys are a more suitable animal model to study the effects of childhood adverse experiences among people and to investigate the development of psychiatric disorders induced by exposure to childhood adversity.
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