糖皮质激素与侵袭性真菌感染

摘要

It is well-known that hyperglucocorticoids play an important role in inducing the fungal infection, especially opportunistic fungal infection,which is attributed to the complex dysregulation of immunity caused by glucocorticoids. The patients, both those with endogenous Cushing's syndrome and, those receiving exogenous glucocorticoid therapy, are especially at risk of invasive fungal infections. A better knowledge of the interplay between glucocorticoid-induced immunosuppression and invasive fungal infections should assist in earlier recognition and establishment of specific prevention and treatment strategies in order to improve outcomes of such infections.%糖皮质激素(激素)是诱发真菌感染、特别是机会性真菌感染重要的因素,可通过抑制免疫反应的多个环节而影响真菌感染的发生与进程.内源性激素相关的疾病如Chushing综合征的患者,以及医源性皮质激素使用的患者均可成为真菌感染的易患人群.正确理解糖皮质激素免疫抑制作用和真菌感染发生的相互关系,可以提高对相关真菌感染的认识并针对性开展防治策略,改善激素应用条件下发生真菌感染的预后.