Objective To investigate the relationship between interleukin-18(IL-18)/interleukin-10(IL-10) ratio and the development of acute coronary syndrome(ACS) in stable angina pectoris(SAP) patients so as to provide new ideas for prevention of ACS. Methods The plasma IL-18 and IL-10 levels were measured by enzyme-linked immunosorbent assay in 215 SAP patients. The patients were divided into 2 groups: ACS group(group A, n=38) and non-ACS group(group B, n=173) according to the results of 24-month follow-up. Results Plasma IL-18 level and IL-18/IL-10 ratio were higher in group A than in group B[(229 ± 77) vs (166 ± 50)ng/L, (2.4 ± 0.7) vs (1.6 ± 0.6) respectively, P < 0.01]. Plasma IL-10 level was lower in group A than in group B[(101 ± 37) vs (115 ± 38)ng/L, P< 0.05]. Logistic regression analysis showed that high IL-18/IL-10 ratio increased the relative risk of ACS in SAP patients by 3.935 times(P< 0.01). Conclusion The plasma IL-18 and IL-10 levels are closely related to the development of ACS in SAP patients. Higher IL-18/IL-10 ratio is predictive of ACS development in SAP patients, which suggests that inflammation is an important enhancing factor for developing ACS, and anti-inflammatory treatment might be a new method for preventing ACS.%目的 探讨白介素(IL) -18/IL-10比值与稳定型心绞痛患者发生急性冠脉综合征的关系,探索防治急性冠脉综合征发生的新途径.方法 采用酶联免疫吸附法检测215例稳定型心绞痛患者IL-18和IL-10的水平变化,并对所有患者进行24个月随访,根据随访的结果将患者分为发生急性冠脉综合征组(A组,38例)及未发生急性冠脉综合征组(B组,173例).结果 A组患者血浆IL-18水平及IL- 18/IL-10比值显著高于B组[(229±77) vs( 166±50) ng/L,(2.4±0.7) vs (1.6±0.6),P＜0.01],A组患者血浆IL-10水平低于B组[(101±37) vs( 115±38) ng/L,P＜0.05]；高血浆IL-18/IL-10比值使稳定型心绞痛患者发生急性冠脉综合征的优势比值增加3.935倍(P＜0.01).结论 稳定型心绞痛患者血浆IL-18和IL-10水平与急性冠脉综合征的发生密切相关；IL-18/IL-10比值增高对稳定型心绞痛患者发生急性冠脉综合征有一定预测价值,提示机体炎症活动增强是促进急性冠脉综合征发生的重要因素,抗炎治疗可能是防治急性冠脉综合征的途径之一.
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