慢性阻塞性肺疾病患者下呼吸道感染铜绿假单胞菌耐药性分析的临床意义研究

摘要

目的 分析慢性阻塞性肺疾病 (COPD) 患者下呼吸道感染铜绿假单胞菌的耐药性, 以便为临床治疗提供参考.方法 100例慢性阻塞性肺疾病合并下呼吸道感染患者, 采集患者的下呼吸道痰液, 进行细菌鉴定及药敏试验, 观察其耐药性.结果 100例患者共培养出病原菌661株, 检测出铜绿假单胞菌113株, 检出率为17.1％.使用15种抗菌药物对113株铜绿假单胞菌进行药敏试验, 耐药率高达60％以上的抗菌药物分别为甲氧苄啶、氨苄西林、替卡西林、头孢噻肟, 亚胺培南耐药率最低.结论 慢性阻塞性肺疾病患者下呼吸道感染铜绿假单胞菌耐药性十分严峻, 临床医生应该加强病原菌耐药性监测, 合理使用抗菌药物.%Objective To analyze the drug resistance of Pseudomonas aeruginosa infection of lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD), so as to provide reference for clinical treatment.Methods The lower respiratory tract sputum of 100 patients with chronic obstructive pulmonary disease and lower respiratory tract infection were collected for bacterial identification and drug susceptibility testing to observe drug resistance.Results A total of 661 strains of original bacteria were cultured in 100 patients, and 113 strains of Pseudomonas aeruginosa were detected, with detection rate as 17.1％.113 strains of Pseudomonas aeruginosa were tested with 15 antimicrobial agents.The antibiotics with the resistance rate of more than 60％were trimethoprim, ampicillin, ticarcillin, cefotaxime and imipenem.The rate of resistance is the lowest.Conclusion The drug resistance of Pseudomonas aeruginosa in lower respiratory tract infection of patients with chronic obstructive pulmonary disease is very severe.Clinicians should strengthen the monitoring of drug resistance of pathogenic bacteria and rationally use antibiotics.