Objective To study the influence of holmium laser lithotripsy under ureteroscopy on stress responses during pregnancy . Methods A total of 56 pregnant patients with ureteral calculi were treated with ureteroscopic holmium laser lithotripsy from August 2011 to May 2015.Another group of 30 pregnant patients with ureteral calculi receiving conservative treatment during the same period were served as the control group .Peripheral blood samples were obtained on the operation morning and first and third postoperative day (or on the first, second, and fourth day after medication in the control group ), and the peripheral blood leucocyte count (WBC), C-reactive protein (CRP), and cortisol concentration (Cor) were compared between the two groups . Results The WBC, CRP, and Cor of the surgery group were declining postoperatively , with significant differences between time points (F=82.92, P=0.000;F=215.01, P=0.000;F=80.89, P=0.000).There was no obvious change in WBC in the control group (F=0.61, P=0.547).The Cor decreased slowly postoperatively in the control group , but with significant difference between the preoperation and fourth postoperative day (q=4.045, P<0.05).On the operation morning, there was no significant difference between the two groups in WBC (t=1.221, P=0.226), but the CRP and Cor were significantly higher in the surgery group than those in the control group (t=2.847, P=0.006; t=2.567, P=0.012).On the first postoperative day (or the second day after medication in the control group), no significant differences in WBC , CRP and Cor were found between the two groups (P>0.05).On the third postoperative day ( or the fourth day after medication in the control group ) , all the three parameters were significantly lower in the surgery group than those in the control group (P<0.05). Conclusion Ureteroscopic holmium laser lithotripsy induces little body ’s stress responses.%目的探讨妊娠期实施输尿管镜钬激光碎石术对机体应激反应的影响。方法2011年8月～2015年5月我院实施输尿管镜钬激光碎石术治疗妊娠合并输尿管结石56例（手术组），与同期保守治疗妊娠合并输尿管结石30例（对照组）进行比较，比较2组术晨、术后第1和3天早晨（分别相当于对照组继续药物治疗第1、2、4天早晨）外周血白细胞计数（WBC）、C－反应蛋白（C-reactive protein，CRP）、皮质醇（Cor）浓度变化。结果手术组术后血WBC、CRP、Cor均呈下降趋势，各指标变化有显著性差异（F＝82．92，P＝0．000；F＝215．01，P＝0．000；F＝80．89，P＝0．000）。对照组继续药物治疗后WBC变化不明显（F＝0．61，P＝0．547），Cor下降缓慢，第4天与术前比较有显著性差异（q＝4．045，P＜0．05）。2组患者术晨WBC无显著性差异（t＝1．221，P＝0畅226），但手术组CRP、Cor明显高于对照组（t＝2．847，P＝0．006；t＝2．567，P＝0．012），2组术后第1天（对照组第2天）3个指标比较无显著性差异（P＞0．05），但手术组术后第3天（对照组第4天）3个指标明显低于对照组（ P＜0畅05）。结论输尿管镜钬激光碎石术对机体的应激反应小。
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