益肾定眩汤联合尤瑞克林治疗急性脑梗死的临床疗效及其对血清C反应蛋白、神经肽Y及皮质醇水平的影响

摘要

Objective To investigate the clinical effect of yi-shen ding-xuan decoction combined with urinarykallid on acute cerebral infarction and its impact on serum levels of CRP,NPY and cortisol. Methods Between 2013 and 2014,a total of 124 patients with acute cerebral infarction were selected in the Department of Neurology,Hankou Hospital of Wuhan,and they were divided into observation group and control group according to random number table,each of 62 cases. Patients of control group were given urinarykallid,while patients of observation group were given yi -shen ding -xuan decoction combined with urinarykallid,both groups treated for 14 days. NIHSS score before treatment and after 24 hours,72 hours,7 days of treatment, serum levels of CRP, NPY and cortisol before and after treatment, clinical effect were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group(u=3. 166,P<0. 05). No statistically significant differences of NIHSS score was found between the two groups before treatment(P>0. 05), while NIHSS score of observation group was statistically significantly lower than that of control group after 24 hours,72 hours,7 days of treatment,respectively(P<0. 05). No statistically significant differences of serum levels of CRP,NPY or cortisol was found between the two groups before treatment(P>0. 05),while serum levels of CRP,NPY and cortisol of observation group were statistically significantly lower than those of control group after treatment(P<0. 05). Conclusion Yi-shen ding-xuan decoction combined with urinarykallid has certain clinical effect on acute cerebral infarction,which can effectively improve the neurological function,reduce the serum levels of CRP,NPY and cortisol.%目的：探讨益肾定眩汤联合尤瑞克林治疗急性脑梗死的临床疗效及其对血清C反应蛋白（ CRP）、神经肽Y（ NPY）及皮质醇水平的影响。方法选取2013—2014年武汉市汉口医院神经内科收治的急性脑梗死患者124例，按照随机数字表法分为观察组和对照组，各62例。对照组患者给予尤瑞克林治疗，观察组患者给予益肾定眩汤联合尤瑞克林治疗，均治疗14 d。比较两组患者治疗前及治疗后24 h、72 h、7 d美国国立卫生研究院卒中量表（ NIHSS）评分，治疗前后血清CRP、NPY及皮质醇水平及临床疗效。结果观察组患者临床疗效优于对照组（ u=3.166，P<0.05）。治疗前两组患者NIHSS评分比较，差异无统计学意义（ P>0.05）；治疗后24 h、72 h、7 d 观察组患者NIHSS评分均低于对照组（P<0.05）。治疗前两组患者血清CRP、NPY及皮质醇水平比较，差异无统计学意义（P>0.05）；治疗后观察组患者血清CRP、NPY及皮质醇水平均低于对照组（ P<0.05）。结论益肾定眩汤联合尤瑞克林治疗急性脑梗死的临床疗效确切，能有效改善患者神经功能，降低血清CRP、NPY和皮质醇水平。