血清肝酶与2型糖尿病及空腹血糖受损的相关性研究

摘要

目的：探讨血清肝酶与2型糖尿病及空腹血糖受损的相关性。方法选取初诊2型糖尿病患者(T2DM组)及空腹血糖受损患者(IFG组)各300例,检测血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白( LDL-C)水平。结果 T2DM 组 ALT、AST、GGT、FBG、TG、LDL-C 水平明显高于 IFG 组(P<0.05)；AST、ALT、GGT三分位分为高水平、中水平、低水平组,高水平组年龄、舒张压、FBG、TG、LDL-C水平与低水平组比较,差异有显著性(P<0.05),Pearson相关分析AST、ALT、GGT均与FBG、TG、LDL-C间具有正相关性(P<0.05)；多元线性逐步回归分析 FBG、TG、LDL-C 水平与 ALT 水平呈正相关(P<0.05)。结论血清肝酶AST、ALT、GGT升高与T2DM、IFG关系密切,FBG、TG、LDL-C水平与ALT水平间呈正相关,提示ALT升高与T2DM、IFG关系最为密切。%Objective To investigate the serum liver enzyme and the correlation of type 2 diabetes mellitus and im-paired fasting glucose. MethOd Select first diagnosis in patients with type 2 diabetes (T2DM) and impaired fasting glucose (IFG) in patients with all the 300 cases, AST,ALT,GGT,FBG,TC,TG,HDL,LDL-C level. Result T2DM group ALT,AST,GGT,FBG,TG,LDL-C level significantly higher than the IFG group (P<0. 05); AST,ALT,the GGT three points are divided into high level, middle level and low level group, the high level group of age,diastolic pressure,FBG,TG,LDL-C level and low level group comparative differences are significant (P<0. 05), pearson correlation analysis of AST, ALT, GGT have positive correlation with the FBG, TG, LDL-C(P<0. 05). Multiple linear stepwise regression analysis of FBG, TG, LDL-C and ALT levels were positively correlated (P<0. 05). COnclusiOn Serum elevated liver enzymes AST, ALT, the GGT closely associated with T2DM, IFG, FBG, TG, LDL-C and ALT levels were positively correlated, the closest relations with T2DM,IFG prompt ALT elevations.