抑郁障碍患者治疗前后执行功能与临床症状变化相关性研究

摘要

目的:探讨抑郁障碍患者治疗前后执行功能与临床症状变化之间的关系.方法:30名抑郁症患者(抑郁组)于治疗前和治疗8周末进行威斯康星卡片分类测验(WCST)、Stroop色词测验、汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评定,同时设正常对照组30例.结果:(1)抑郁组治疗后WCST测查评分较治疗前有显著改善(P＜0.01).Stroop测查治疗后有改善,前后比较无统计学意义P＞0.05.(2)抑郁障碍患者治疗前后WCST测验正确数、完成分类数减分与HAMA精神性焦虑因子减分呈中等负相关(r=-0.571、-0.637,P＜0.05);WCST错误数、持续性错误数减分与HAMA精神性焦虑因子减分呈中等正相关(r=0.558、0.621,P＜0.05),Stroop测验与HAMD-17、HAMA及其因子无明显相关.结论:抑郁障碍患者执行功能改善与焦虑症状改善之间有相关性.%Objective: To investigate the relation of executive function and clinical symptom variety of depressive disorders patients before and after treatment. Methods: 30 depressive disorders patients was analyzed by Wisconsin card sorting test(WCST), Stroop chromoword test, hamilton's depression scale (HAMD-17), hamilton anxiety scale (HAMA) before treatment and after 8 week treatment. 30 normal control groups was established. Results: (1) Wisconsin card sorting test grade of depressive disorders groups was significantly improved compareed with beginning of treatment, P＜0.01; Stroop chromo-word test was improved after treatment, and there was not statistical significance P＞0.05. (2) Deduction of WCST correction value and completed cluster number was medium negative correlation with deduction of HAMA psychic anxiety factor (r=-0.571,-0.637,P＜0.05), deduction of WCST error value, persistent errors value was medium positive correlation with deduction of HAMA psychic anxiety facto (r=0.558, 0.621, P＜0.05), Stroop chromo-word test was no significant correlation with HAMD-17, HAMA. Conclusions: This study suggests that there was relationship between executive function improvement and anxiety disorders improvement in depressive disorders patients.