两种不同治疗方法对老年性阴道炎的复发疗效比较

摘要

Objective:Estriol two group therapy, in the treatment of senile vaginitis clinical effect. Methods:2011 January to 2012 December in our hospital gynecological clinics in 100 cases of senile vaginitis patients, were randomly divided into two groups (except for one case quit):the observation group (49 cases) and control group (50 cases). The two groups were vaginal administration, began using metronidazole tablets 0.2g, 1 times a day, for 7 days, in the observation group after treatment with metronidazole estriol cream 0.5g, 1 times a day, for 14 days, then 2 times a week, maintenance therapy for 8 weeks;in the control group after treatment with metronidazole Lactobacillus capsule 0.5g daily, for 14 days, then 2 times a week, maintenance therapy for 8 weeks. Comparison of two different treatment methods in clinical application effects. Results:①In the vagina after treatment for 3 weeks, the observation group and the control group in the total efficiency was 100%.②3 months after treatment in two groups of patients followed up at the time of relapse rate was 0%, 4, 5, and 6 months, the observation group recurrence rates were:4.08%, 8.16%, 20.41%, as the control group of recurrence rates were:20%, 26%, 42%, the difference between the two groups was statistically significance (P=0.03, P=0.04, P=0.04). The observation group has 4 cases with breast swelling and vaginal burning sensation, no adverse reaction occurred in the control group. Conclusion:Estriol cream in the prevention of senile vaginitis recurrence than Lactobacillus capsule. On the safety aspects of Lactobacillus capsule is more than estriol.%　　目的：探讨甲硝唑+乳酸菌与甲硝唑+雌三醇两组治疗方法,对治疗老年性阴道炎的临床效果。方法：选择2011年1月～2012年12月在本院妇科门诊就诊的老年性阴道炎患者100例,随机分为两组：因中途1例退出雌三醇治疗,即观察组为49例,对照组为50例。两组阴道给药,开始均使用甲硝唑片0.2g/次,1次/天,连用7天,观察组在甲硝唑治疗结束后用雌三醇乳膏0.5g/次,1次/天,连用14天,之后改每周2次,维持治疗8周；对照组在甲硝唑治疗结束后用乳酸菌胶囊0.25g /粒,2粒/天,连用14天,之后改每周2次,维持治疗8周。比较两组临床应用效果。结果：①在阴道用药3周后,观察组和对照组的总有效率均为100%。②在治疗后第2、3个月对两组患者随访时复发率均为0%,在第4、5、6个月时,观察组复发率分别为：4.08%、8.16%、20.41%,照组复发率分别为：20.00%、26.00%、42.00%,两组间比较差异有统计学意义(P=0.03、P=0.04、P=0.04)。③观察组有4例患者出现乳胀及阴道灼热感,对照组无不良反应。结论：雌三醇乳膏在预防老年性阴道炎复发方面优于乳酸菌胶囊。在用药安全性方面乳酸菌胶囊更胜一筹。