肾衰患者中测定血清肌钙蛋白I和肌酸激酶同工酶II的价值分析

摘要

Objective:To investigate the renal failure patients serum troponin I and creatine kinase isoenzymeⅡexpression and clinical diagnosis value.Methods:The ELISA method and enzyme dynamics method were determined in our hospital from 2009 April to 2010 April included 68 cases of renal failure patients between ( observation group) and 68 healthy subjects ( control group) of serum cardiac troponin I and creatine kinase isoenzymeⅡexpression.Results:In the observation group, the patients of cardiac troponin I and creatine kinase isoenzymeⅡwere significantly higher than those in the control group of cardiac troponin I and creatine kinase isoenzymeⅡcontent, the difference was significant (P<0.05);and the severity of renal failure in serum cardiac troponin I and creatine kinase isoenzymeⅡwere significantly higher than that of severity in the light of serum cardiac troponin I and creatine kinase isoenzymeⅡcontent, two groups of data comparison, the difference was significant (P<0.05), statistically meaningful.Conclusion:Renal failure patients serum cardiac troponin I and creatine kinase isoenzymeⅡhave abnormal expression, but as the disease severity in the serum content is also rising, can be used as an important index in diagnosis of renal failure patients.%目的：探讨肾衰患者血清中肌钙蛋白I与肌酸激酶同工酶Ⅱ的表达情况以及临床诊断价值。方法：采取ELISA法和酶动力法分别进行测定我院2009年4月到2010年4月之间收录的68例肾衰患者(观察组)与同期68名健康的对象(对照组)的血清中心肌肌钙蛋白I与肌酸激酶同工酶Ⅱ的表达情况。结果：观察组的患者肌钙蛋白Ⅰ与肌酸激酶同工酶Ⅱ的含量均明显的高于对照组的肌钙蛋白Ⅰ与肌酸激酶同工酶Ⅱ的含量，差异具有显著性(P<0.05)；而且肾衰病情严重的血清中的肌钙蛋白Ⅰ与肌酸激酶同工酶Ⅱ的含量明显的高于病情程度轻血清中的肌钙蛋白Ⅰ与肌酸激酶同工酶Ⅱ的含量情况，两组的数据比较，差异具有显著性(P<0.05)，统计学有意义。结论：肾衰患者血清中肌钙蛋白Ⅰ与肌酸激酶同工酶Ⅱ得到异常表达，而且随着病情程度的加重其血清中的含量也不断的上升，可以作为肾衰患者病情诊断的重要指标物。