盐酸羟考酮注射液用于全身麻醉患者术后镇痛的前瞻性、对照性研究

摘要

目的：探讨盐酸羟考酮注射液用于全身麻醉（全麻）患者术后镇痛的临床效果。方法：选择94例老年关节置换术患者，按照随机数表法分为两组，每组47例，均接受全麻，术后镇痛分别予以盐酸羟考酮注射液镇痛和硫酸吗啡注射液镇痛。观察两组镇痛后2、24、48h的疼痛视觉模拟评分(Visual Analogue Scale/Score，VAS）情况以及补救镇痛情况和不良反应发生率、镇痛效果满意率，并进行比较。结果：镇痛后2h，两组VAS评分经比较不存在统计学意义（P＞0.05）；镇痛后24、48h，观察组的VAS评分均显著低于同时点对照组，经比较差异有统计学意义（P＜0.05）。镇痛过程中，观察组的补救镇痛率为12.77%（6/47），显著低于对照组的34.04%（16/47），经比较差异有统计学意义（P＜0.05）。观察组的不良反应发生率为10.64%（5/47），显著低于对照组的21.28%（10/47），经比较差异有统计学意义（P＜0.05）。观察组对镇痛效果的满意率为97.87%（46/47），显著高于对照组的80.85%（38/47），经比较差异有统计学意义（P＜0.05）。结论：全麻患者术后进行镇痛的过程中，较之硫酸吗啡注射液镇痛，使用盐酸羟考酮注射液镇痛可以获得更好的效果，且不良反应较少，是一种安全、有效的镇痛方法。%Objective: To explore the effect influence of oxycodone hydrochloride injection for postoperative analgesia in patients undergoing general anesthesia.Methods:94 cases of elderly patients undergoing joint replacement surgery,according to a random number table method is divided into two groups,47cases in each group.All patients received general anesthesia,postoperative analgesia were to be oxycodone hydrochloride injection analgesia and morphine sulfate injection analgesia.Observe two groups of analgesia after 2,24,and 48 h pain visual simulation score (visual analogue Scale/Score,VAS) and remedy the analgesia and adverse reactions occurred,and analgesic effect of satisfaction rates,and were compared.Results:2 h after analgesia,VAS scores by comparison was not statistically significant (P>0.05);analgesia after 24 and 48 hours.In the observation group,the VAS scores were significantly lower than those of the control group,the difference has statistical significance (P<0.05).In the course of analgesia,the recovery of the observation group was 12.77%(6/47), significantly lower than that of the control group 34.04%(16/47),and the difference was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was 10.64%(5/47),significantly lower than the control group 21.28%(10/47),the difference was statistically significant (P<0.05).The satisfaction rate of the observation group for analgesic effect was 97.87%(46/47),significantly higher than that of the control group 80.85%(38/47) the difference was statistically significant (P<0.05).Conclusion:After general anesthesia analgesic,compared with morphine sulfate injection analgesia,the use of oxycodone hydrochloride injection analgesia can obtain better effect and less adverse reaction, it is a safe and effective method of analgesia.