Objective: To investigate interleukin -18 (IL-18) and urinary kidney injury molecule -1 (KIM-1) levels in patients with varying degrees of burn patients with acute kidney injury (AKI) The clinical significance of early diagnosis.Methods:80 cases of hospitalized burn patients in our hospital from January 2011 to January 2014, Press the burn area and depth of mild, moderate and severe burn group,volunteers as a control group. Blood and urine specimens were detected in blood levels of full term; ELISA assay and analysis of urinary KIM-1 and IL-18 levels and the degree burns.Results:(1)mild, moderate, severe and control groups urinary KIM-1 levels were significantly higher (P<0.05); and urine IL-18 level difference between the three groups of patients and the control group was not statistically significance.(2)severe burns merger urinary KIM-1 and IL-18 levels were significantly higher AKI severe burn patients without AKI merger,the differences were statistically significant (P<0.05), and urinary KIM-1 and IL-18 increased early in elevated serum creatinine.(3)urinary KIM-1 was positively correlated with serum BUN, Scr was, but with ALB was negatively correlated (P<0.05).Urine and serum IL-18 Cr low correlation, but with serum BUN, ALB no correlation.Conclusion:Urinary IL-18, KIM-1 can be used as predictive AKI patients with varying degrees of burns sensitive early indicator for burn prevention in patients with early clinical AKI provide some clues.%目的：探讨白细胞介素-18（IL-18）及尿肾损伤分子-1（KIM-1）水平在不同程度烧伤患者合并急性肾损伤（AKI）早期诊断中的临床意义。方法：选择2011年1至2014年1月收治的80例住院烧伤患者，按烧伤面积和深度分轻、中及重度烧伤组，体检者为对照组。分别留取血液及尿液，检测血全项水平；ELISA法检测和分析尿KIM-1及IL-18水平与烧伤程度等。结果：（1）轻、中、重度组及对照组的尿KIM-1水平均明显高于对照组（P＜0.05）；而三组患者及对照组的尿IL-18水平比较差异无统计学意义。（2）重度烧伤合并AKI患者尿KIM-1及IL-18水平明显高于重度烧伤不合并AKI患者，差异均有统计学意义（P＜0.05），且尿KIM-1及IL-18升高早于血肌酐升高。（3）尿KIM-1与血清BUN、Scr呈正相关，但与ALB呈负相关（P均＜0.05）。尿IL-18与血清Cr低度相关，但与血清BUN、ALB无相关性。结论：尿IL-18、KIM-1可以作为预测不同程度烧伤患者合并AKI的早期敏感指标，为烧伤患者早期预防AKI提供一定的临床线索。
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