抗结核药致药物性肝炎的治疗效果评估及研究

摘要

Objective:To evaluate the therapeutic effect of antituberculosis drugs on drug-induced hepatitis.Methods:Patients with drug-induced hepatitis caused by anti tuberculosis drugs in 60 cases,were randomly divided into control group and experimental group,30 cases each,two groups were treated with routine treatment,the experimental group based on the use of L-ornithine-L-aspartate,improve liver function changes and symptoms were compared between the two groups after treatment.ResultAfter treatment,the ALT,gamma-GT,AST,TBiL indexes in the experimental group were lower than those in the control group,the average time of symptom disappearance was shorter than that of the control group,the difference between the two groups was significant (P ＜ 0.05).Conclusion:The use of L-omithine-L-aspartate in clinical anti tuberculosis drug induced hepatitis,can effectively improve the clinical symptoms and liver function of patients,is worthy of promotion.%目的:评估分析抗结核药物致药物性肝炎的治疗效果.方法:60例抗结核药致药物性肝炎患者参与研究,按照入院顺序随机均分为对照组和试验组,各30例,两组均实施常规基础治疗,试验组基于此加用门冬氨酸鸟氨酸,比较两组患者治疗后肝功能变化情况以及症状改善情况.结果:试验组患者治疗后ALT、γ-GT、AST、TBiL指标均低于对照组,症状消失平均时间比对照组短,组间比较差异明显(P＜0.05).结论:在抗结核药致药物性肝炎的临床中使用门冬氨酸鸟氨酸,可有效改善患者临床症状和肝功能.