Objective:To assess the clinical efficacy of refractory gastric ulcer by HuangqiJianzhong Decoction combined withproton pump inhibitor's quadruple sequential therapy.Methods:From Jan 2013 to Jan 2015,our hospital 84 cases of refractory ulcer patients were randomly divided into observation group and control group.The observation group with Huangqi Jianzhong Decoction combined withproton punp inhibitor'squadruple sequential therapy,the control group using proton pump inhibitors'quadruple sequential therapy.The therapeutic effects of two groups were observed.After 8 weeks of discontinuation of urea breath test,Helicobacter pylori eradication rate statistics.Results:Cure patients in the observation group accounted for 73.81％,accounting for 11.90％ of patients were cured,improved in patients accounted for 9.52％,accounting for 4.76％ of patients invalid.The control group were 47.62％,11.90％,7.14％ and 33.33％,statistical difference was statistically significant (P ＜ 0.05).Conclusion:Huangqi Jianzhong Decoction combined with proton punp inhibitors' four sequential therapy for the treatment of refractory gastric ulcer has obvious curative effect,and better clearance of helicobacter pylori irffection effect.%目的:探讨黄芪建中汤联合质子泵抑制剂四联序贯疗法治疗难治性胃溃疡的临床疗效.方法:2013年1月至2015年1月,我院收治难治性胃溃疡患者84例,随机分为观察组和对照组.观察组采用黄芪建中汤联合质子泵抑制剂四联序贯疗法治疗,对照组采用质子泵抑制剂四联序贯疗法治疗.观察两组患者的治疗疗效.停药8周后进行尿素酶呼气试验,统计幽门螺杆菌的根除率.结果:观察组的治愈患者占73.81％,显效患者占11.90％,好转患者占9.52％,无效患者占4.76％.对照组分别为47.62％、11.90％、7.14％和33.33％,统计差异有统计学意义(P＜0.05).结论:黄芪建中汤联合质子泵抑制剂四联序贯疗法治疗难治性胃溃疡疗效显著,并且清除幽门螺旋杆菌感染的效果较好.
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