(E)-4-酰氧基苯基丙烯酸类衍生物的合成及抑癌活性

摘要

报道了18个(E)-4-酰氧基苯基丙烯酸类衍生物的设计与合成。其中17个化合物未见文献报道。所有目标物的化学结构经元素分析、红外光谱和核磁共振氢谱确证。初步体外抑癌试验结果表明，化合物3e、3f、3g、3h、3k、4h和4j在0.3 μmol·L-1浓度下对小鼠艾氏腹水癌(EAC)呈现显著抑制作用。%In the paper the design and synthesis of eighteen compounds of(E)-3-substituted- 4-aryloxyphenylpropenoic acid were reported.Among them seventeen final target compounds had never been reported.The chemical structures of all the target compounds were determined by elementary analysis and IR as well as 1H-NMR,etc.Preliminary results of anticancer tests in vitro showed that the test compounds 3e,3f,3g,3h,3k,4h and 4j had significantly anticancer activities on Ehrlich ascites carcinoma at 0.3 mmol·L-1 concentration.