目的：分别采用Excel和CMRtools（2012）软件计算重型β地中海贫血患者的T2*值，探讨两者评价铁过载患者T2*值的一致性和可替代性。资料与方法将27例重型β地中海贫血患者的T2*图像直接导入CMRtools（2012），在图像上勾画感兴趣区，去除干扰信号后直接计算出T2*值；在MRI自带软件中测量T2*图像感兴趣区的信号值，手工输入Excel中，去除干扰信号后计算出T2*值，比较两种方法测量肝脏及心肌铁过载T2*值的差异。结果27例重型β地中海贫血患者中，心肌铁过载10例，肝脏铁过载25例。Excel和CMRtools（2012）软件计算的心肌及肝脏T2*值差异无统计学意义（t=－0.152、－0.691，P>0.05）。结论 Excel和CMRtools（2012）软件在评价铁过载患者的T2*值方面具有很好的一致性，临床上可以应用Excel评价重型β地中海贫血患者的铁过载情况。%PurposeTo assess the level of agreement and interchangeability among Excel and CMRtools (2012) for calculation of T2* values in iron overload.Materials and Methods T2* images in 27 cases withβ-thalassemia major were imported into CMRtools (2012). The regions of interest (ROI) were drawn and interference signal removed to obtain T2* values. The T2* images were also measured using default MR software and manually entered into Excel to obtain T2* values after removal of the interference signal. The agreement between the two methods in calculating T2* values was compared.Results For 27 patients withβ-thalassemia major, 10 cases showed myocardial iron overload. 25 cases had liver iron overload. The T2* values from two methods were not statistically significant (t=-0.152 and-0.691,P>0.05) for the liver.Conclusion There is good agreement and interchangeability between Excel and CMRtools (2012) in calculating T2* values. Excel can be used clinically to evaluate iron overload.
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