Objective To assess the significance of VVI in early diagnosis of coronary heart disease (CHD ) and evaluation of therapeutic ef'fect of percutaneous transluminal coronary angioplasty (PTCA ) plus stent implantation . Methods VVI software was used to analyze systolic peak velocity (Vs ) , strain (ε) , systolic and early-diastolic strain rate (SRs , SRe ) of 9 segments supplied by lef't anterior descending (LAD ) in CHD group ( n= 21) before and 7 days after PTCA+stent therapy . Then the results were compared with those of 23 normal controls ( control group) . Results Vs , ε . SR. and SRe of 9 segments supplied by LAD were obviously lower in CHD group than in control group before therapy (all P＜ 0. 05) . The ε in most segments improved 7 days after PTCA+stent therapy (all P＜ 0. 05) . but still lower than that in control group (all P＜ 0. 05 ) . Conclusion VVI can quantitatively analyze the left ventricular regional myocardial systolic functional changes in 7 days after PTCA+stent therapy . It has important significance for judging prognosis of CHD and evaluating therapeutic efficacy of PTCA .%目的 探讨VVI在早期诊断冠心病(CHD)和评价经皮冠状动脉成形术(PTCA)+支架植入术疗效的意义.方法 利用VVI软件分析CHD组(n=21)支架植入术前1天、术后7天左前降支(LAD)供血的9个节段的收缩期峰值速度(Vs)、应变(ε)、应变率(SRs、SRe),并与对照组(23名正常人)比较.结果 CHD组术前LAD供血的9节段Vs、ε、SRs、SRe明显低于对照组相应节段(P均<0.05);PTCA+支架植入术后7天,大部分节段ε较术前均显著提高(P均<0.05),但与对照组仍有差异(P均<0.05).结论 VVI技术可无创定量评价PTCA术后早期疗效,对于评价CHD患者PTCA治疗后的恢复情况有重要意义.
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